Panic Disorder is one type of anxiety disorder character¬ized by sudden onset of intense physical and cognitive symptoms of anxiety and can occur unexpectedly or as a trigger to stress. Screening questionnaire like MACSCREEN may be employed. Multiple hypotheses are advanced to understand the underpinnings of panic disorder. Both nonpharmacological and pharmacological manage-ment have to be employed. Cognitive behaviour therapy including mindfulness therapy, breathing exercises, relax-ation techniques and importantly psychoeducation are the nonpharmacological methods. Pharmacological management involves serotonin selective antidepressants and benzodiazepines (acute stage) with level 1 evidence where as other agents with level 3evidence include antidepressants with different mechanism, atypical antipsychotics and probably anticonvulsants. Technological advances including wearable devices collecting real-time data, 'big data' platforms, and applica-tion of machine learning techniques might assist in reliable outcome prediction.

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